ABSTRACT
PurposeThis study aims to empirically examine the knowledge, social and religious factors effecting the intention to receive COVID-19 vaccination while considering the mediating role of attitude towards COVID-19 vaccination. The research explores how the Islamic ideologies shape Muslims' knowledge, social and religious beliefs towards COVID-19 vaccination acceptance or refusal.Design/methodology/approachTheoretically, the study is based on the functional theory of attitudes. The model of the study is comprised of nine variables explaining the attitude and intention towards COVID-19 vaccination. Among nine variables, perceived Islamic religiosity, perceived behavioural control and Halal consciousness among Muslims are explained through the value-expressive function of attitude. Furthermore, the perceived risk of COVID-19, the perceived side effect of COVID-19 vaccination and the perceived efficacy of COVID-19 vaccination are considered in the model based on the utility function of attitude. Moreover, social influence for COVID vaccination, subjective norms and group conformity are ed from the social-adjustive function of attitude. This study used a quantitative survey research method to test the hypotheses. A total of 1,000 questionnaires were distributed to non-vaccinated Muslim respondents from five cities in Pakistan. The structural equation modelling (SEM) technique was used to test the relationship among the variables in the proposed model. The partial least square-SEM method explained the variances in the dependent variables. Moreover, to test the structure of data, different statistical tests, including exploratory factor analysis (EFA), factor loadings and average variance extracted, were used with the help of Statistical Package for the Social Sciences (SPSS) and analysis of a moment structures (AMOS) 23.0 version.FindingsResults for direct effect showed a significant negative effect of Islamic religiosity, perceived behavioural control, halal consciousness, perceived side effect of COVID-19 vaccination, social influence, subjective norm and group conformity on attitude towards COVID-19 vaccination. In contrast, insignificant results showed no relationship of perceived risk from COVID-19 infection and perceived efficacy of COVID-19 vaccination with attitude towards COVID-19 vaccination. Results for mediating effect showed the significant negative mediating effect of attitude towards COVID-19 vaccination between Islamic religiosity, perceived behavioural control, halal consciousness, perceived side effect, social influence, subjective norm, group conformity and intention to receive COVID-19 vaccination. While results showed the insignificant mediation of attitude towards COVID-19 between perceived risk from COVID-19 infection, perceived efficacy of COVID-19 vaccination and intention to receive COVID-19 vaccination.Research limitations/implicationsFurther studies are required to compare the attitude and intention among the temporary refusal group (those who will consider vaccination the future) and the permanent refusal group (those who will not consider vaccination the future). Comparing Muslim and non-Muslim groups can also explain differences in attitude and intention towards COVID-19 vaccination.Originality/valueThe area of acceptance and refusal of COVID-19 vaccination has been given limited attention in academic literature. Theoretically, this research has proposed a well-defined model to explain the attitude of Muslims towards COVID-19 vaccination. This model can helpf predict the attitude and intentions of Muslims towards vaccination or medicines. Moreover, this research is a unique contribution for the vaccination brands to consider the discussed factors before launching their brand in Muslim countries.
ABSTRACT
Studiul s-a concentrat pe determinarea politicilor guvernamentale esenţiale si a barierelor comerciale care afectează performanţa exporturilor industriei textile în timpul pandemiei de COVID-19. Acest studiu a analizat influenţa politicilor guvernamentale de export asupra performanţei la export a industriei textile. Acest studiu a comparat, de asemenea, factori din trei industrii textile din Asia de Sud, respectiv Pakistan, India si Bangladesh. Studiul a identificat nouă politici guvernamentale de export esenţiale si bariere comerciale bazate pe vizualizarea organizaţiei industriale (Vizualizarea I/O). A fost utilizat un model de regresie de tip panel pentru a analiza semnificaţia fiecărei politici guvernamentale si barierele comerciale care afectează performanţa exporturilor de produse textile. Rezultatele studiului au arătat că ratele de schimb valutar, costul de export, timpul de export, stabilitatea politică a ţării, calitatea infrastructurii din ţară, libertatea din corupţie, costul de afaceri al terorismului si stabilitatea economică în ţară au un efect semnificativ asupra performanţei la export a industriei. În schimb, taxele pentru desfăşurarea afacerilor au un efect nesemnificativ asupra performanţei la export. Testul de Estimare aparent fără legătură (SUEST) a comparat diferenţele de performanţă la export ale industriilor textile din Pakistan, India si Bangladesh datorate politicilor guvernamentale. Rezultatele au arătat că un nivel mai ridicat de timp pentru export, costul de export si costul pentru desfăsurarea afacerilor terorismului duc la performanţa scăzută la export a industriei textile. În acelasi timp, un nivel mai ridicat al cursurilor de schimb valutar, stabilitatea politică a ţării, calitatea infrastructurii, libertatea din corupţie si stabilitatea economică în ţară duc la performanţe ridicate la export ale industriei textile. Mai mult, taxele pentru desfăsurarea afacerilor au un efect nesemnificativ asupra performanţei la export. Acest studiu este printre puţinele care abordează industria textilă în timpul pandemiei de COVID-19. Din cauza circumstanţelor incerte, va fi greu pentru guvern să identifice factori importanţi care ar putea ajuta exportatorii de textile să supravieţuiască si să se dezvolte în timpul pandemiei de COVID-19. Studiul a identificat politici guvernamentale importante si bariere comerciale care afectează exporturile de textile pe baza unui sprijin teoretic solid si a comparat si a elaborat, de asemenea, importanţa fiecărui factor în trei ţări din Asia de Sud. Acest studiu va ajuta factorii de decizie să-si reconsidere factorii legaţi de export pentru a-si spori exporturile de textile si pentru a-si relansa economia după pandemia de COVID-19.Alternate :The study focused on determining essential government policies and trade barriers affecting the textile industry's export performance during the COVID-19 pandemic. This study has analysed the effect of government export policies on the export performance of the textile industry. This study has also compared factors among three South Asian textile industries, including Pakistan, India, and Bangladesh. The study identified nine essential government export policies and trade barriers based on Industrial Organization View (I/O View). A panel regression model was used to analyse the significance of each government policy and trade barrier affecting textile export performance. Results of the study showed that currency exchange rates, the cost to export, time to export, political stability of the country, quality of infrastructure in the country, freedom from corruption, business cost of terrorism and economic stability in the country have a significant effect on export performance of the industry. In contrast, taxes on doing business have an insignificant effect on export performance. The Seemingly Unrelated Estimation (SUEST) test compared the differences in export performance of Pakistani, Indian and Bangladeshi textile industries due to governmen policies. The results showed that a higher level of time to export, cost to export and business cost of terrorism lead to the low export performance of the textile industry. At the same time, a higher level of currency exchange rates, political stability of the country, quality of infrastructure, freedom from corruption and economic stability in-country lead to the high export performance of the textile industry. Further, taxes on doing business have an insignificant effect on export performance. This study is among the few contributing to the textile industry during the COVID-19 pandemic. Due to uncertain circumstances, it becomes hard for the government to identify important factors which could help textile exporters to survive and grow during the COVID-19 pandemic. The study has identified important government policies and trade barriers affecting textile exports based on strong theoretical support and has also compared and elaborated on the importance of each factor across three South Asian countries. This study will help policymakers reconsider exportrelated factors to enhance their textile exports and revive their economy after the COVID-19 pandemic.
ABSTRACT
This study empirically examines the spillovers from global uncertainties to the sectoral indices of the Pakistan stock market (PSX). Furthermore, we select three major sectoral indices, i.e., the energy, financial, and material composite indices. These indices represent a massive capital volume of PSX. We utilize the data from 10 May 2002 to 27 June 2022 to examine the outbreak due to the global financial crisis (GFC) of 2007-2008 and the impact of the world's great pandemic, of COVID-19. Additionally, we applied a novel econometric estimation approach: quantile connectedness. We found that connectedness is strong in the case of highly positive changes (above the 20% quantile) and highly negative changes (below the 80% quantile). Additionally, the study also found that materials sector is the least connected at level of 1.58%. In contrast, the financial sector was a strong transmitter of spillovers during the entire study period at connectedness of 54.59%. Regarding graphical results, we found that economic policy uncertainty (EPU) and crude oil index (WTI) are net transmitters, especially during the financial crisis and COVID-19, whereas WTI transmitting impact was significantly dominant during GFC 2007-2008. Conversely, the index MSCI remains the recipient of the spillover during the entire study period, where the remitting effect was observed as dominant during the GFC, and COVID-19 outbreak. The energy sector was found to be more recipient during the GFC, with additional turn transmitters of the shocks after the COVID-19 pandemic. The study recommends that portfolio managers and individual investors consider the materials sector for their investment due to the least connectivity. Similarly, investors need to invest carefully in the financial sector because it is a net transmitter of spillovers to other sectors.
ABSTRACT
Understanding the co-movement and lag–lead relations among indices is integral to financial decision making. These parameters show the reactiveness of the market towards new information. Understanding them helps to minimize risk and facilitates optimal portfolio diversification. By employing the wavelet coherence econometric model, the authors of this study analyzed the intricate relations among the Bond and Ṣukūk indices using global data belonging to the United States (US), the United Kingdom (UK), Middle East and North Africa (MENA), and Gulf Cooperation Council (GCC) countries. The findings indicated the presence of strong but similar implications of the initial shock of COVID-19 deaths on both Islamic and conventional markets’ volatilities, especially in long-term investment bands (64–128 days). The results oppose the general belief that Islamic finance is more sustainable and less volatile to crises than its traditional counterparts. Moreover, the authors of this study report diverse relationships among bond and Ṣukūk indices throughout the sample periods. We consistently found low correlations in short-term investment bands (4–16), leading to optimal diversification opportunities. However, high correlations were reported due to COVID-19 in the long-term investment bands (128–256), leading to low diversification opportunities for long-term investors.
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes 16 non-structural proteins (NSPs), four structural proteins, and nine accessory proteins that play indispensable roles to suppress the production and signaling of type I and III interferons (IFNs). In this review, we discussed the functions and the underlying mechanisms of different proteins of SARS-CoV-2 that evade the host immune system by suppressing the IFN-β production and TANK-binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3)/signal transducer and activator of transcription (STAT)1 and STAT2 phosphorylation. We also described different viral proteins inhibiting the nuclear translocation of IRF3, nuclear factor-κB (NF-κB), and STATs. To date, the following proteins of SARS-CoV-2 including NSP1, NSP6, NSP8, NSP12, NSP13, NSP14, NSP15, open reading frame (ORF)3a, ORF6, ORF8, ORF9b, ORF10, and Membrane (M) protein have been well studied. However, the detailed mechanisms of immune evasion by NSP5, ORF3b, ORF9c, and Nucleocapsid (N) proteins are not well elucidated. Additionally, we also elaborated the perspectives of SARS-CoV-2 proteins.
ABSTRACT
Objectives This study was conducted to evaluate COVID-19 vaccine booster dose willingness and identify predictors and factors of willingness and hesitance in the vaccinated population of Pakistan. Methods A cross-sectional web-based survey was undertaken between January and February 2022 to highlight the public perceptions regarding the COVID-19 booster dose and evaluate the willingness to get the additional dose. Demographic information and booster dose willingness were recorded through the questionnaire. Additionally, a 5-point Likert scale was employed to explore fears and beliefs regarding COVID-19 vaccinations. Univariate and multivariate regression was performed to identify booster dose willingness and hesitance factors. Results Of the 787 respondents, 69.6% were females, 75.3% fell in the 18–30 years age group, 53.5% were university students or had a Bachelor's degree. Overall, a 77.8% booster dose willingness was reported. Participants showed absence or low fear levels associated with a booster dose (47.3%). 60.1% agreed it was safe to receive an additional vaccine dose, with 44.1% agreeing that boosters are effective against coronavirus variants. Independent predictors of willingness included the absence of comorbidities, whereas not being willing to pay for the booster dose was a predictor of hesitance. Conclusion This study showed a suboptimal willingness level of booster dose uptake among the vaccinated Pakistani population. Public health policymakers must undertake necessary awareness campaigns to strategize vaccination drives and dispel myths.
ABSTRACT
Introduction: During the pandemic, sedentary behaviors, anxiety, and boredom caused by confinement at home could affect lifestyle patterns, degrade diet quality, and promote overconsumption. This cross-sectional study aimed to identify the impact of lockdowns on lifestyle behaviors among Pakistan's population and changes in the nutritional and eating patterns. Materials and Methods: This is an online, questionnaire-based, cross-sectional study. The study collected demographic information, dietary habits, and lifestyle patterns. Descriptive and summary statistics were used to describe data, and Chi-square or Fisher's exact tests were used for associations. Results: Most respondents were females (82.1%) aged 18-29 years (98.1%). 90.3% of them were students. 16.0% were overweight pre-pandemic, which increased to 20.0% during the pandemic. The majority ate more during the pandemic (P < 0.001). 47.9% reported a physical activity duration of 0.5-2 h pre-pandemic, and 50.6% reported decreased physical activity during the pandemic, with increased food intake (P = 0.007). Screen time was <4 h for most (48.8%) participants pre-pandemic, and the majority (89.7%) of respondents reported an increased screen time during the pandemic, associated with a higher food intake (47.9%, P = 0.029). Conclusion: The pandemic has negatively impacted lifestyles and diets, including a significant decrease in physical activity, increased food intake, and increased screen time.
ABSTRACT
Continuing reports of new SARS-CoV-2 variants have caused worldwide concern and created a challenging situation for clinicians. The recently reported variant B.1.618, which possesses the E484K mutation specific to the receptor-binding domain (RBD), as well as two deletions of Tyr145 and His146 at the N-terminal binding domain (NTD) of the spike protein, must be studied in depth to devise new therapeutic options. Structural variants reported in the RBD and NTD may play essential roles in the increased pathogenicity of this SARS-CoV-2 new variant. We explored the binding differences and structural-dynamic features of the B.1.618 variant using structural and biomolecular simulation approaches. Our results revealed that the E484K mutation in the RBD slightly altered the binding affinity through affecting the hydrogen bonding network. We also observed that the flexibility of three important loops in the RBD required for binding was increased, which may improve the conformational optimization and consequently binding of the new variant. Furthermore, we found that deletions of Tyr145 and His146 at the NTD reduced the binding affinity of the monoclonal antibody (mAb) 4A8, and that the hydrogen bonding network was significantly affected consequently. This data show that the new B.1.618 variant is an antibody-escaping variant with slightly altered ACE2–RBD affinity. Moreover, we provide insights into the binding and structural-dynamics changes resulting from novel mutations in the RBD and NTD. Our results suggest the need for further in vitro and in vivo studies that will facilitate the development of possible therapies for new variants such as B.1.618. This study explored the binding patterns of the wild type and B.1.618 variant using which revealed that the B.1.618 variant possess a stronger binding affinity for the host ACE2 and escape the neutralizing antibodies.
ABSTRACT
Background and Objectives: The purpose of this study was to draw the attention toward the implications of COVID-19 and the related restrictions imposed worldwide especially in Pakistan. The primary objective was to highlight the levels of psychological distress, anxiety, family violence, suicidality, and well-being due to COVID-19 and the secondary objective was to associate it to social demographic factors. Materials and Methods: It is designed as a cross-sectional study by employing an online questionnaire in the English language and obtaining responses using a snowball sampling technique. We used three validated measures including Kessler Psychological Distress Scale (K10), Generalized Anxiety Disorder (GAD-7) index and World Health Organization Well-Being Index (WHO-5). Results: A sample of 420 participants was recruited from across Pakistan, with most participants were females (79%), students (89.8%) and belonging to Punjab (54%). Nearly one-fourth of the participants (23.8%) scored above the minimum value set for moderate or high psychological distress (K10 > 12). There was a higher prevalence of distress among females and resident of province Punjab. The majority of individuals reported that they were living with their family (94.5%) and more than half (52.6%) were neutral regarding their satisfaction with their living conditions. 40.5% believed that the lockdown has had a negative impact on their mental health. 31.4% have reported that they themselves have experienced abuse from a family member. 48.6% scored high on the GAD-7 scale and low wellbeing score was found among 80.2%. Students were found to be more vulnerable to mental illness and anxiety. Conclusion: With the lockdown restrictions, psychosocial distress has become prevalent in Pakistan.
ABSTRACT
Background and Objectives: During the pandemic, the growing influence of social media, accessibility of over-the-counter medications, and fear of contracting the virus may have led to self-medication practices among the general public. Medical students are prone to such practices due to relevant background knowledge, and access to drugs. This study was carried out to determine and analyze the prevalence of self-medication practices among medical students in Pakistan. Materials and Methods: This descriptive, cross-sectional study was conducted online in which the participants were asked about the general demographics, their self-medication practices and the reasons to use. All participants were currently enrolled in a medical college pursuing medical or pharmacy degree. Non-probability sampling technique was used to recruit participants. Results: A total of 489 respondents were included in the final analysis. The response rate was 61%. Majority of the respondents were females and 18-20 years of age. Self-medication was quite prevalent in our study population with 406 out of 489 individuals (83.0%) were using any of the drugs since the start of pandemic. The most commonly utilized medications were Paracetamol (65.2%) and multivitamins (56.0%). The reasons reported for usage of these medications included cold/flu, or preventive measures for COVID-19. The common symptoms reported for self-medication included fever (67.9%), muscle pain (54.0%), fatigue (51.7%), sore throat (46.6%), and cough (44.4%). Paracetamol was the most commonly used drug for all symptoms. Female gender, being in 3rd year of medical studies, and individuals with good self-reported health were found more frequent users of self-medication practices. Conclusion: Our study revealed common self-medication practices among medical and pharmacy students. It is a significant health issue especially during the pandemic times, with high consumption reported as a prevention or treating symptoms of COVID-19.
Subject(s)
COVID-19 , Students, Medical , COVID-19/epidemiology , Cross-Sectional Studies , Female , Humans , Pandemics , Self MedicationABSTRACT
TOPIC: Lung Pathology TYPE: Fellow Case Reports INTRODUCTION: We present a diagnostic challenging case of spindle cell thymoma mimicking a left lung upper lobe mass along the mediastinal pleura. CASE PRESENTATION: A 54-year-old female is hospitalized with hypoxic respiratory failure due to COVID 19 pneumonia. Patient developed ARDS, pneumomediastinum, and septic shock with secondary bacterial infection requiring mechanical ventilator support and antibiotic therapy. Patient had a prolonged complicated hospital course with multiorgan failure including kidney injury, lacunar stroke and developed severe critical illness myopathy. Patient underwent tracheostomy and was discharge to long term acute care facility to wean from the ventilator. Due to persistent need of supplemental oxygen and intermittent tachycardia, chest X ray was performed which showed alveolar and interstitial infiltrates. Subsequently, CT angiogram chest was performed which showed no pulmonary embolism but a 7 cm left lung upper lobe mass extending from hilum along the mediastinum. Positron emission tomography (PET) performed showed minimal uptake in the mass without enhanced uptake in any other location. Percutaneous biopsy was pursued which showed numerous oval spindle cells clusters with rare lymphocyte suggestive of spindle cell thymoma. During rehabilitation, patient was later diagnosed with myasthenia gravis and planned to undergo thymectomy after functional status of the patient improves. DISCUSSION: Thymomas are the most common epithelial cell tumor of the anterior mediastinum composed of neoplastic epithelial cells with a variable number of lymphocytes which determines various histologic subtypes of thymic neoplasms based on Worl Health Organization (WHO) classification. Histologic subtyping of thymoma need complete resection of tumor but core biopsy can differentiate thymoma from carcinoma. Our patient had WHO type A spindle cell thymoma which is composed of fusiform or oval spindle cells with rare lymphocytes. It accounts for 22% of all thymomas with no gender predilection and mean age of diagnosis is sixth decade. Thymomas are commonly located in prevascular anterior mediastinum but, rarely, as described in our patient it can present as hilar mass extending along the mediastinal pleural into the left upper lobe which can mimic lung tumor. Prognosis is based on resectability of tumor, staging and histologic features. CONCLUSIONS: Thymomas can mimic lung malignancy on imaging studies and need histologic exam to confirm the diagnosis. REFERENCE #1: The histomorphologic spectrum of spindle cell thymoma. Annikka Weissferdt MD, FRCPath⁎, Cesar A. Moran MD, PMID: 23260329 DISCLOSURES: No relevant relationships by Yusra Ansari, source=Web Response No relevant relationships by Priyanka Bhat, source=Web Response No relevant relationships by Tahir Muhammad Abdullah Khan, source=Web Response No relevant relationships by Karan Singh, source=Web Response
ABSTRACT
Developing countries like Pakistan have previously suffered from barriers to acceptance of vaccination by the public because of financial and belief barriers. This study aims to explore these beliefs and highlight concerns regarding vaccine hesitancy in the general population of Pakistan since they are a hindrance to an effective coronavirus disease-19 (COVID-19) immunization in the country. A cross-sectional study was performed involving 1,778 participants from all four provinces of Pakistan. Results from the study showed more than half of the participants to be unsure of the safety (50%) and efficacy (51%) of the vaccine, whereas 42% were concerned about the side effects of the vaccine. About 72% of the respondents planned to get vaccinated, whereas 28% refused to do so. Internationally made imported vaccines were more trusted by the participants. Forty-four percent of the participants agreed to receive the vaccine upon recommendation from a physician. Lastly, participants who believed in the efficacy of the polio vaccination also considered the COVID-19 vaccine to be safe and effective.
Subject(s)
COVID-19 Vaccines/administration & dosage , COVID-19/prevention & control , Culture , Patient Acceptance of Health Care , Vaccination Hesitancy/psychology , Vaccination/psychology , Adolescent , Adult , Cross-Sectional Studies , Drug-Related Side Effects and Adverse Reactions , Female , Humans , Male , Middle Aged , Pakistan , Surveys and Questionnaires , Young AdultABSTRACT
The tribal belt of the Hindu Kush mountains is famous for its unique culture, ethnography, wild food plants, food systems, and traditional knowledge. People in this region gather wild plants and plant parts using them directly or in traditional cuisine, or sell them in local markets. However, there is a huge lack of documentation of the food system, particularly that related to wild food plants (WFP). In the current study, we focus on the uses and contributions of WFPs in the traditional tribal food system of the Hindu Kush valleys along the Pakistan–Afghanistan border. Ethnobotanical data were gathered through questionnaire surveys of 84 informants, including 69 men and 15 women, belonging to 21 different villages of the chosen area. In tribal societies men and women rarely mix and thus very few women took part in the surveys. We documented 63 WFP species belonging to 34 botanical families, of which 27 were used as vegetables, 24 as fruits, six in different kinds of chutneys (starters), and six as fresh food species. Fruits were the most used part (41%), followed by leaves (24%), aerial parts (24%), seeds (7%), stems (3%), and young inflorescences (1%). The reported uses of Carthamus oxyacantha, Pinus roxburghii seeds, and Marsilea quadrifolia leaves are novel for the gastronomy of Pakistan. The results reveal that WFPs provide a significant contribution to local food systems and play a role in addressing human nutritional needs, which are usually not met through farming practices. The tribal peoples of the Hindu Kush use WFPs for their nutritional value, but also as a cultural practice—an inseparable component of the tribal community’s lifestyle. This important traditional knowledge about the gathering and consumption of WFPs, however, is eroding at an alarming rate among younger generations due to the introduction of fast-food, modernization, and globalization. Therefore, appropriate strategies are imperative not only to safeguard traditional plants and food knowledge and practices, as well as the cultural heritage attached to them, but also to foster food security and thus public healthcare via local wild foods in the region.
ABSTRACT
Objective Thrombotic complications and vasculopathy have been extensively associated with severe COVID-19 infection, however the mechanisms by which endotheliitis is induced remain poorly understood. Here we investigate vascular permeability in the context of SARS-CoV-2-mediated endotheliitis in patient samples and a vascular organoid model. Methods and Results We report the presence of the Spike glycoprotein in pericytes associated with pericyte activation and increased endothelial permeability in post-mortem COVID-19 lung autopsies. A pronounced decrease in the expression of the adhesion molecule VE-cadherin is observed in patients with thrombotic complications. Interestingly, fibrin-rich thrombi did not contain platelets, did not colocalize with tissue factor and have heterogenous levels of Von Willebrand factor, suggesting a biomarker-guided therapy might be required to target thrombosis in severe patients. Using a 3D vascular organoid model, we observe that ACE2 is primarily expressed in pericytes adjacent to vascular networks, consistent with patient data, indicating a preferential uptake of the S glycoprotein by these cells. Exposure of vascular organoids to SARS-CoV-2 or its antigens, recombinant trimeric Spike glycoprotein and Nucleocapsid protein, reduced endothelial cell and pericyte viability as well as CD144 expression with no additive effect upon endothelial activation via IL-1β. Conclusions Our data suggest that pericyte uptake of SARS-CoV-2 or Spike glycoprotein contributes to vasculopathy by altering endothelial permeability increasing the risk of thrombotic complications.